1. Can I combine multiple transaction sets (i.e., X12 270/271 and X12 835) in a single companion guide?
Yes. Entities, may, if they wish, combine their companion guides for separate transactions into a single document. The flow and format of the CAQH CORE Master Companion Guide template would still need to be followed, but sections could be repeated, tables added for the second transaction, etc., without altering said flow and format.